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Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels
Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, play an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small mole...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563359/ https://www.ncbi.nlm.nih.gov/pubmed/22929778 http://dx.doi.org/10.1038/ncomms2017 |