Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products

OBJECTIVE: Develop and validate particular, concrete, and abstract yet plausible in silico mechanistic explanations for large intra- and interindividual variability observed for eleven bioequivalence study participants. Do so in the face of considerable uncertainty about mechanisms. METHODS: We cons...

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Detalles Bibliográficos
Autores principales: Kim, Sean HJ, Jackson, Andre J, Hur, Rim, Hunt, C Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563477/
https://www.ncbi.nlm.nih.gov/pubmed/22938185
http://dx.doi.org/10.1186/1742-4682-9-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563477/
https://www.ncbi.nlm.nih.gov/pubmed/22938185
http://dx.doi.org/10.1186/1742-4682-9-39

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