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The Prolyl Isomerase Pin1 Acts Synergistically with CDK2 to Regulate the Basal Activity of Estrogen Receptor α in Breast Cancer

In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol. Anti-estrogens, such as tamoxifen, have been used as the first line of therapy for over three decades due to the fact that they elici...

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Detalles Bibliográficos
Autores principales: Lucchetti, Chiara, Caligiuri, Isabella, Toffoli, Giuseppe, Giordano, Antonio, Rizzolio, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563590/
https://www.ncbi.nlm.nih.gov/pubmed/23390529
http://dx.doi.org/10.1371/journal.pone.0055355