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Inhibition of Myelin-Cleaving Poteolytic Activities by Interferon-Beta in Rat Astrocyte Cultures. Comparative Analysis between Gelatinases and Calpain-II

BACKGROUND: Proteolytic enzymes have been implicated in the pathogenesis of Multiple Sclerosis (MS) for both their ability to degrade myelin proteins and for their presence in MS plaques.In this study we investigated whether interferon-beta (IFN-β) could differently modulate the activity and the exp...

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Detalles Bibliográficos
Autores principales: Latronico, Tiziana, Branà, Maria Teresa, Gramegna, Pasqua, Fasano, Anna, Di Bari, Gaetano, Liuzzi, Grazia Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563665/
https://www.ncbi.nlm.nih.gov/pubmed/23390485
http://dx.doi.org/10.1371/journal.pone.0049656