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Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay

During animal development, SDF1 simultaneously guides various cell types to different targets. As many targets are in close proximity to one another, it is unclear how the system avoids mistargeting. Zebrafish trigeminal sensory neurons express the SDF1 receptor Cxcr4b and encounter multiple SDF1 so...

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Detalles Bibliográficos
Autores principales: Lewellis, Stephen W., Nagelberg, Danielle, Subedi, Abhi, Staton, Alison, LeBlanc, Michelle, Giraldez, Antonio, Knaut, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563679/
https://www.ncbi.nlm.nih.gov/pubmed/23382464
http://dx.doi.org/10.1083/jcb.201207099