Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme

Biased codon usage in protein-coding genes is pervasive, whereby amino acids are largely encoded by a specific subset of possible codons. Within individual genes, codon bias is stronger at evolutionarily conserved residues, favoring codons recognized by abundant tRNAs. Although this observation sugg...

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Detalles Bibliográficos
Autores principales: Agashe, Deepa, Martinez-Gomez, N. Cecilia, Drummond, D. Allan, Marx, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563975/
https://www.ncbi.nlm.nih.gov/pubmed/23223712
http://dx.doi.org/10.1093/molbev/mss273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563975/
https://www.ncbi.nlm.nih.gov/pubmed/23223712
http://dx.doi.org/10.1093/molbev/mss273

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