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Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax

Resistance to TRAIL (TNF-related apoptosis-inducing ligand)- induced apoptosis limits its therapeutic use. Different strategies of TRAIL sensitization and a dependency on Bax have been reported, but common principles of TRAIL resistance and the way of Bax activation remained poorly understood. Apply...

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Detalles Bibliográficos
Autores principales:	Berger, A, Quast, S-A, Plötz, M, Kammermeier, A, Eberle, J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563986/ https://www.ncbi.nlm.nih.gov/pubmed/23348591 http://dx.doi.org/10.1038/cddis.2012.198

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