Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms

Ras activation is a frequent event in human hepatocarcinoma that may contribute to resistance towards apoptosis. Salirasib is a ras and mTOR inhibitor that induces a pro-apoptotic phenotype in human hepatocarcinoma cell lines. In this work, we evaluate whether salirasib sensitizes those cells to TRA...

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Detalles Bibliográficos
Autores principales: Charette, N, De Saeger, C, Horsmans, Y, Leclercq, I, Stärkel, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563988/
https://www.ncbi.nlm.nih.gov/pubmed/23348585
http://dx.doi.org/10.1038/cddis.2012.200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563988/
https://www.ncbi.nlm.nih.gov/pubmed/23348585
http://dx.doi.org/10.1038/cddis.2012.200

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