TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent mechanisms. It has been assumed that because RIPK1 bears a death domain (DD), but RIPK3 does not, RIPK1 is necessary for recruitment of RIPK3 i...

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Detalles Bibliográficos
Autores principales: Moujalled, D M, Cook, W D, Okamoto, T, Murphy, J, Lawlor, K E, Vince, J E, Vaux, D L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563989/
https://www.ncbi.nlm.nih.gov/pubmed/23328672
http://dx.doi.org/10.1038/cddis.2012.201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563989/
https://www.ncbi.nlm.nih.gov/pubmed/23328672
http://dx.doi.org/10.1038/cddis.2012.201

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