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Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet

High doses of rapamycin, an antiaging agent, can prevent obesity in mice on high fat diet (HFD). Obesity is usually associated with hyperinsulinemia. Here, we showed that rapamycin given orally, at doses that did not affect weight gain in male mice on HFD, tended to decrease fasting insulin levels....

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Detalles Bibliográficos
Autores principales: Leontieva, O V, Paszkiewicz, G, Demidenko, Z N, Blagosklonny, M V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563990/
https://www.ncbi.nlm.nih.gov/pubmed/23348586
http://dx.doi.org/10.1038/cddis.2012.202