Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest

Increasing evidence suggests that tumor-initiating cells (TICs), also called cancer stem cells, are partly responsible for resistance to DNA-damaging treatment. Here we addressed if such a phenotype may contribute to radio- and cisplatin resistance in non-small cell lung cancer (NSCLC). We showed th...

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Detalles Bibliográficos
Autores principales: Lundholm, L, Hååg, P, Zong, D, Juntti, T, Mörk, B, Lewensohn, R, Viktorsson, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563998/
https://www.ncbi.nlm.nih.gov/pubmed/23370278
http://dx.doi.org/10.1038/cddis.2012.211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563998/
https://www.ncbi.nlm.nih.gov/pubmed/23370278
http://dx.doi.org/10.1038/cddis.2012.211

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