Approaches for Identification of HIV-1 Entry Inhibitors Targeting gp41 Pocket

The hydrophobic pocket in the HIV-1 gp41 N-terminal heptad repeat (NHR) domain plays an important role in viral fusion and entry into the host cell, and serves as an attractive target for development of HIV-1 fusion/entry inhibitors. The peptide anti-HIV drug targeting gp41 NHR, T-20 (generic name:...

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Detalles Bibliográficos
Autores principales: Yu, Fei, Lu, Lu, Du, Lanying, Zhu, Xiaojie, Debnath, Asim K., Jiang, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564113/
https://www.ncbi.nlm.nih.gov/pubmed/23344560
http://dx.doi.org/10.3390/v5010127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564113/
https://www.ncbi.nlm.nih.gov/pubmed/23344560
http://dx.doi.org/10.3390/v5010127

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