Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

FK506 (Tacrolimus) is a potent inhibitor of calcineurin that blocks IL2 production and is widely used to prevent transplant rejection and treat autoimmunity. FK506 treatment of dendritic cells (FKDC) limits their capacity to stimulate T cell responses. FK506 does not prevent DC survival, maturation,...

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Detalles Bibliográficos
Autores principales: Orange, Dana E, Blachere, Nathalie E, Fak, John, Parveen, Salina, Frank, Mayu O, Herre, Margo, Tian, Suyan, Monette, Sebastien, Darnell, Robert B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564474/
https://www.ncbi.nlm.nih.gov/pubmed/23390586
http://dx.doi.org/10.7554/eLife.00105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564474/
https://www.ncbi.nlm.nih.gov/pubmed/23390586
http://dx.doi.org/10.7554/eLife.00105

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