Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

Sterol-induced binding to Insigs in endoplasmic reticulum (ER) membranes triggers ubiquitination of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reductase. This ubiquitination, which is mediated by Insig-associated ubiquitin ligases gp78 and Trc8, is obligatory for extraction o...

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Detalles Bibliográficos
Autores principales: Jo, Youngah, Hartman, Isamu Z., DeBose-Boyd, Russell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564538/
https://www.ncbi.nlm.nih.gov/pubmed/23223569
http://dx.doi.org/10.1091/mbc.E12-07-0564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564538/
https://www.ncbi.nlm.nih.gov/pubmed/23223569
http://dx.doi.org/10.1091/mbc.E12-07-0564

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