Evolutionary principles and synthetic biology: avoiding a molecular tragedy of the commons with an engineered phage

BACKGROUND: In prior work, adding a gene to phage T7 that degraded the host K1 capsule facilitated growth when plated on capsulated hosts. However, the transgenic protein (an endosialidase) is expressed as an exoenzyme, released from the cell at lysis but unattached to the phage particle. There is t...

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Detalles Bibliográficos
Autores principales: Gladstone, Eric G, Molineux, Ian J, Bull, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564837/
https://www.ncbi.nlm.nih.gov/pubmed/22947166
http://dx.doi.org/10.1186/1754-1611-6-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564837/
https://www.ncbi.nlm.nih.gov/pubmed/22947166
http://dx.doi.org/10.1186/1754-1611-6-13

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