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Evolutionary principles and synthetic biology: avoiding a molecular tragedy of the commons with an engineered phage
BACKGROUND: In prior work, adding a gene to phage T7 that degraded the host K1 capsule facilitated growth when plated on capsulated hosts. However, the transgenic protein (an endosialidase) is expressed as an exoenzyme, released from the cell at lysis but unattached to the phage particle. There is t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564837/ https://www.ncbi.nlm.nih.gov/pubmed/22947166 http://dx.doi.org/10.1186/1754-1611-6-13 |