Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics

Prion diseases are fatal neurodegenerative diseases associated with the conversion of cellular prion protein (PrP(C)) in the central nervous system into the infectious isoform (PrP(Sc)). The mechanics of conversion are almost entirely unknown, with understanding stymied by the lack of an atomic-leve...

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Detalles Bibliográficos
Autores principales: Jetha, Nahid N., Semenchenko, Valentyna, Wishart, David S., Cashman, Neil R., Marziali, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564863/
https://www.ncbi.nlm.nih.gov/pubmed/23393562
http://dx.doi.org/10.1371/journal.pone.0054982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564863/
https://www.ncbi.nlm.nih.gov/pubmed/23393562
http://dx.doi.org/10.1371/journal.pone.0054982

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