Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12

BACKGROUND: An adenovirus that expresses both interleukin (IL)-12 and granulocyte-macrophage colony-stimulating-factor (GM-CSF) has been proven to be very effective in treating several tumors, but causes serious normal tissue toxicities. METHODS: In this study, a novel adenoviral vector was construc...

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Detalles Bibliográficos
Autores principales: Wei, Fang, Wang, Huiping, Zhang, Jufeng, Chen, Xiafang, Li, Chuanyuan, Huang, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564871/
https://www.ncbi.nlm.nih.gov/pubmed/23352035
http://dx.doi.org/10.1186/1756-9966-32-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564871/
https://www.ncbi.nlm.nih.gov/pubmed/23352035
http://dx.doi.org/10.1186/1756-9966-32-5

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