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Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12

BACKGROUND: An adenovirus that expresses both interleukin (IL)-12 and granulocyte-macrophage colony-stimulating-factor (GM-CSF) has been proven to be very effective in treating several tumors, but causes serious normal tissue toxicities. METHODS: In this study, a novel adenoviral vector was construc...

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Detalles Bibliográficos
Autores principales:	Wei, Fang, Wang, Huiping, Zhang, Jufeng, Chen, Xiafang, Li, Chuanyuan, Huang, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564871/ https://www.ncbi.nlm.nih.gov/pubmed/23352035 http://dx.doi.org/10.1186/1756-9966-32-5

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