Generation and characterization of monospecific and bispecific hexavalent trimerbodies

Here, we describe a new class of multivalent and multispecific antibody-based reagents for therapy. The molecules, termed “trimerbodies,” use a modified version of the N-terminal trimerization region of human collagen XVIII noncollagenous 1 domain flanked by two flexible linkers as trimerizing scaff...

Descripción completa

Detalles Bibliográficos
Autores principales: Blanco-Toribio, Ana, Sainz-Pastor, Noelia, Álvarez-Cienfuegos, Ana, Merino, Nekane, Cuesta, Ángel M., Sánchez-Martín, David, Bonet, Jaume, Santos-Valle, Patricia, Sanz, Laura, Oliva, Baldo, Blanco, Francisco J., Álvarez-Vallina, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564888/
https://www.ncbi.nlm.nih.gov/pubmed/23221741
http://dx.doi.org/10.4161/mabs.22698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564888/
https://www.ncbi.nlm.nih.gov/pubmed/23221741
http://dx.doi.org/10.4161/mabs.22698

Ejemplares similares