Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork

The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions between tumor-specific somatic mutations and a second-site target gene. One hallmark of most cancers that can be exploited by chemotherapies is...

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Detalles Bibliográficos
Autores principales: van Pel, Derek M., Stirling, Peter C., Minaker, Sean W., Sipahimalani, Payal, Hieter, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564987/
https://www.ncbi.nlm.nih.gov/pubmed/23390603
http://dx.doi.org/10.1534/g3.112.004754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564987/
https://www.ncbi.nlm.nih.gov/pubmed/23390603
http://dx.doi.org/10.1534/g3.112.004754

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