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Microscopic mechanism of protein cryopreservation in an aqueous solution with trehalose

In order to investigate the cryoprotective mechanism of trehalose on proteins, we use molecular dynamics computer simulations to study the microscopic dynamics of water upon cooling in an aqueous solution of lysozyme and trehalose. We find that the presence of trehalose causes global retardation of...

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Detalles Bibliográficos
Autores principales: Corradini, Dario, Strekalova, Elena G., Stanley, H. Eugene, Gallo, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565168/
https://www.ncbi.nlm.nih.gov/pubmed/23390573
http://dx.doi.org/10.1038/srep01218