Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15

The novel compound JRS-15 was obtained through the chemical modification of xylocydine. JRS-15 exhibited much stronger cytotoxic and pro-apoptotic activity than its parent compound in various cancer cell lines, with IC(50) values in HeLa, HepG2, SK-HEP-1, PC-3M and A549 cells ranging from 12.42 to 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Chao, Guo, Xiao-Xi, Zhu, Dan, Xiao, Chuan, Bai, Xiao, Li, Yang, Zhan, Zhuo, Li, Xiang-Long, Song, Zhi-Guang, Jin, Ying-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565295/
https://www.ncbi.nlm.nih.gov/pubmed/23344045
http://dx.doi.org/10.3390/ijms14010850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565295/
https://www.ncbi.nlm.nih.gov/pubmed/23344045
http://dx.doi.org/10.3390/ijms14010850

Ejemplares similares