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On the binding affinity of macromolecular interactions: daring to ask why proteins interact

Interactions between proteins are orchestrated in a precise and time-dependent manner, underlying cellular function. The binding affinity, defined as the strength of these interactions, is translated into physico-chemical terms in the dissociation constant (K(d)), the latter being an experimental me...

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Detalles Bibliográficos
Autores principales: Kastritis, Panagiotis L., Bonvin, Alexandre M. J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565702/
https://www.ncbi.nlm.nih.gov/pubmed/23235262
http://dx.doi.org/10.1098/rsif.2012.0835