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On the binding affinity of macromolecular interactions: daring to ask why proteins interact
Interactions between proteins are orchestrated in a precise and time-dependent manner, underlying cellular function. The binding affinity, defined as the strength of these interactions, is translated into physico-chemical terms in the dissociation constant (K(d)), the latter being an experimental me...
Autores principales: | Kastritis, Panagiotis L., Bonvin, Alexandre M. J. J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565702/ https://www.ncbi.nlm.nih.gov/pubmed/23235262 http://dx.doi.org/10.1098/rsif.2012.0835 |
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