Integrated copy number and gene expression analysis detects a CREB1 association with Alzheimer's disease

Genetic variation, both single-nucleotide variations and copy number variations (CNV), contribute to changes in gene expression. In some cases these variations are meaningfully correlated with disease states. We hypothesized that in a genetically heterogeneous disorder such as sporadic Alzheimer...

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Detalles Bibliográficos
Autores principales: Li, Y, Shaw, C A, Sheffer, I, Sule, N, Powell, S Z, Dawson, B, Zaidi, S N Y, Bucasas, K L, Lupski, J R, Wilhelmsen, K C, Doody, R, Szigeti, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565761/
https://www.ncbi.nlm.nih.gov/pubmed/23168992
http://dx.doi.org/10.1038/tp.2012.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565761/
https://www.ncbi.nlm.nih.gov/pubmed/23168992
http://dx.doi.org/10.1038/tp.2012.119

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