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Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells
BACKGROUND: p53 is the most frequently mutated tumor-suppressor gene in human cancers. It has been reported that mutations in p53 result not only in the loss of its ability as a tumor suppressor, but also in the gain of novel cancer-related functions that contribute to oncogenesis. The present study...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565885/ https://www.ncbi.nlm.nih.gov/pubmed/23356234 http://dx.doi.org/10.1186/1477-7819-11-22 |