Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization. In this study, on the hunt for pantothenate analogues with incre...

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Detalles Bibliográficos
Autores principales: Spry, Christina, Macuamule, Cristiano, Lin, Zhiyang, Virga, Kristopher G., Lee, Richard E., Strauss, Erick, Saliba, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566143/
https://www.ncbi.nlm.nih.gov/pubmed/23405100
http://dx.doi.org/10.1371/journal.pone.0054974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566143/
https://www.ncbi.nlm.nih.gov/pubmed/23405100
http://dx.doi.org/10.1371/journal.pone.0054974

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