An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells

Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5. We o...

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Detalles Bibliográficos
Autores principales: Sousa, Mirta M. L., Zub, Kamila Anna, Aas, Per Arne, Hanssen-Bauer, Audun, Demirovic, Aida, Sarno, Antonio, Tian, Erming, Liabakk, Nina B., Slupphaug, Geir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566207/
https://www.ncbi.nlm.nih.gov/pubmed/23405159
http://dx.doi.org/10.1371/journal.pone.0055493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566207/
https://www.ncbi.nlm.nih.gov/pubmed/23405159
http://dx.doi.org/10.1371/journal.pone.0055493

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