Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci

The presence of DNA double-stranded breaks in a mammalian cell typically activates the Non-Homologous End Joining (NHEJ) pathway to repair the damage and signal to downstream systems that govern cellular decisions such as apoptosis or senescence. The signalling system also stimulates effects such as...

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Detalles Bibliográficos
Autores principales: Dolan, David, Nelson, Glyn, Zupanic, Anze, Smith, Graham, Shanley, Daryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566652/
https://www.ncbi.nlm.nih.gov/pubmed/23457464
http://dx.doi.org/10.1371/journal.pone.0055190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566652/
https://www.ncbi.nlm.nih.gov/pubmed/23457464
http://dx.doi.org/10.1371/journal.pone.0055190

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