Cargando…

Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci

The presence of DNA double-stranded breaks in a mammalian cell typically activates the Non-Homologous End Joining (NHEJ) pathway to repair the damage and signal to downstream systems that govern cellular decisions such as apoptosis or senescence. The signalling system also stimulates effects such as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolan, David, Nelson, Glyn, Zupanic, Anze, Smith, Graham, Shanley, Daryl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566652/ https://www.ncbi.nlm.nih.gov/pubmed/23457464 http://dx.doi.org/10.1371/journal.pone.0055190

Ejemplares similares

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86
por: Beskow, C, et al.
Publicado: (2009)

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ
por: Schellenbauer, Amelie, et al.
Publicado: (2021)

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling
por: Dolan, David W. P., et al.
Publicado: (2015)

EAF2 regulates DNA repair through Ku70/Ku80 in the prostate
por: Ai, J, et al.
Publicado: (2017)

The Multifaceted Roles of Ku70/80
por: Zahid, Sayma, et al.
Publicado: (2021)

Evidence for Ku70/Ku80 association with full-length RAG1
por: Raval, Prafulla, et al.
Publicado: (2008)

NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase
por: Knyazhanskaya, Ekaterina, et al.
Publicado: (2019)

PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair
por: Pan, Qimei, et al.
Publicado: (2023)

Biochemical evidence for Ku-independent backup pathways of NHEJ
por: Wang, Huichen, et al.
Publicado: (2020)

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties
por: Inagawa, Takabumi, et al.
Publicado: (2020)

The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
por: Reynolds, Pamela, et al.
Publicado: (2012)

Molecular characterization of KU70 and KU80 homologues and exploitation of a KU70-deficient mutant for improving gene deletion frequency in Rhodosporidium toruloides
por: Koh, Chong Mei John, et al.
Publicado: (2014)

Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
por: Lv, Shidong, et al.
Publicado: (2022)

DNA damage response and Ku80 function in the vertebrate embryo
por: Bladen, Catherine L., et al.
Publicado: (2005)

Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells
por: Shi, Lingfang, et al.
Publicado: (2007)

Ku70 and Ku80 participate in LPS-induced pro-inflammatory cytokines production in human macrophages and monocytes
por: Sun, Hong, et al.
Publicado: (2020)

Inactivating Mutations of the IK Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy
por: Gao, Chao, et al.
Publicado: (2021)

SAP domain forms a flexible part of DNA aperture in Ku70/80
por: Hnízda, Aleš, et al.
Publicado: (2021)

Transcriptome dataset of HEK293T cells depleted of one of the subunits of the DNA-PK complex: Ku70, Ku80 or DNA-PKcs
por: Anisenko, Andrey, et al.
Publicado: (2021)

Impact of Amino Acid Substitutions in Two Functional Domains of Ku80: DNA-Damage-Sensing Ability of Ku80 and Survival after Irradiation
por: KOIKE, Manabu, et al.
Publicado: (2013)

Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression
por: Li, Jingjing, et al.
Publicado: (2018)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
por: Wang, Minli, et al.
Publicado: (2006)

Cloning of canine Ku80 and its localization and accumulation at DNA damage sites
por: Koike, Manabu, et al.
Publicado: (2017)

Nuclear localization of mouse Ku70 in interphase cells and focus formation of mouse Ku70 at DNA damage sites immediately after irradiation
por: KOIKE, Manabu, et al.
Publicado: (2015)

Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression
por: Grote, Jens, et al.
Publicado: (2006)

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage
por: Nishi, Ryotaro, et al.
Publicado: (2018)

Cloning, localization and focus formation at DNA damage sites of canine Ku70
por: KOIKE, Manabu, et al.
Publicado: (2017)

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
por: Ting, Nicholas S. Y., et al.
Publicado: (2005)

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
por: Kefala Stavridi, Antonia, et al.
Publicado: (2023)

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks
por: Parvathaneni, Swetha, et al.
Publicado: (2013)

Cytoplasm-Translocated Ku70/80 Complex Sensing of HBV DNA Induces Hepatitis-Associated Chemokine Secretion
por: Li, Young, et al.
Publicado: (2016)

Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway
por: Baek, Kyung Hye, et al.
Publicado: (2016)

Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in Response to DNA Damage
por: Zhang, Chengwan, et al.
Publicado: (2013)

Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells
por: Li, Baomin, et al.
Publicado: (2011)

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres
por: Ribes-Zamora, Albert, et al.
Publicado: (2013)

Differential Recruitment of DNA Repair Proteins KU70/80 and RAD51 upon Microbeam Irradiation with α-Particles
por: Bobyk, Laure, et al.
Publicado: (2022)

Lack of Ku80 Alteration in Multiple Myeloma
por: Kato, Miyuki, et al.
Publicado: (2002)

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage
por: Abbasi, Sanna, et al.
Publicado: (2023)

Deacetylation of Ku70 regulates ionizing-radiation induced DNA damage responses in human cells
por: Al-Emam, Ahmed, et al.
Publicado: (2014)

Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response
por: Fell, Victoria L., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vipb3ihq58rvfulm7kntjkkl10