RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis

Current antidepressants, which inhibit the serotonin transporter (SERT), display limited efficacy and slow onset of action. Here, we show that partial reduction of SERT expression by small interference RNA (SERT-siRNA) decreased immobility in the tail suspension test, displaying an antidepressant po...

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Detalles Bibliográficos
Autores principales: Ferrés-Coy, A, Pilar-Cuellar, F, Vidal, R, Paz, V, Masana, M, Cortés, R, Carmona, M C, Campa, L, Pazos, Á, Montefeltro, A, Valdizán, E M, Artigas, F, Bortolozzi, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566716/
https://www.ncbi.nlm.nih.gov/pubmed/23321808
http://dx.doi.org/10.1038/tp.2012.135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566716/
https://www.ncbi.nlm.nih.gov/pubmed/23321808
http://dx.doi.org/10.1038/tp.2012.135

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