A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth

BACKGROUND: This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours. METHODS: We evaluated the effect of a novel inhibitor, C1A, on HDAC6 biochemical activity and cell growth. We further examined potential of early noninvasive...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaliszczak, M, Trousil, S, Åberg, O, Perumal, M, Nguyen, Q-D, Aboagye, E O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566806/
https://www.ncbi.nlm.nih.gov/pubmed/23322205
http://dx.doi.org/10.1038/bjc.2012.576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566806/
https://www.ncbi.nlm.nih.gov/pubmed/23322205
http://dx.doi.org/10.1038/bjc.2012.576

Ejemplares similares