Cargando…

Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells

BACKGROUND: Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of the forkhead transcription factors' family, FoxO3a, has been implicated in the expression of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carbajo-Pescador, S, Steinmetz, C, Kashyap, A, Lorenz, S, Mauriz, J L, Heise, M, Galle, P R, González-Gallego, J, Strand, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566813/ https://www.ncbi.nlm.nih.gov/pubmed/23257900 http://dx.doi.org/10.1038/bjc.2012.563

Ejemplares similares

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells
por: Carbajo-Pescador, S, et al.
Publicado: (2013)

Genome-wide analysis of FoxO1 binding in hepatic chromatin: Potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis
por: Shin, Dong-Ju, et al.
Publicado: (2012)

Palmitate induces fat accumulation via repressing FoxO1-mediated ATGL-dependent lipolysis in HepG2 hepatocytes
por: Zhao, Naiqian, et al.
Publicado: (2021)

Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK/FoxO3a/Bim Pathway
por: Chen, Xingwang, et al.
Publicado: (2022)

Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy
por: Prieto-Domínguez, Néstor, et al.
Publicado: (2017)

CHIP Regulates AKT/FoxO/Bim Signaling in MCF7 and MCF10A Cells
por: Lv, Yanrong, et al.
Publicado: (2013)

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid
por: Sanphui, P, et al.
Publicado: (2013)

Idelalisib promotes Bim-dependent apoptosis through AKT/FoxO3a in hepatocellular carcinoma
por: Yue, Dan, et al.
Publicado: (2018)

Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes
por: Yang, Won-Mo, et al.
Publicado: (2017)

MiR-144-3p Targets FoxO1 to Reduce Its Regulation of Adiponectin and Promote Adipogenesis
por: Lin, Weimin, et al.
Publicado: (2020)

Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells
por: Zhao, Xiangxuan, et al.
Publicado: (2014)

Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway
por: Chi, Hsiang-Cheng, et al.
Publicado: (2016)

Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner
por: Wu, Yao, et al.
Publicado: (2020)

Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway
por: Alaaeldin, Rania, et al.
Publicado: (2021)

lncRNA–mRNA competing endogenous RNA network in IR-hepG2 cells ameliorated by APBBR decreasing ROS levels: a systematic analysis
por: Lin, Min, et al.
Publicado: (2020)

Effects and Mechanism of Oxymatrine Combined with Compound Yinchen Granules on the Apoptosis of Hepatocytes through the Akt/FoxO3a/Bim Pathway
por: Zhang, Xian, et al.
Publicado: (2022)

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells
por: Luo, H, et al.
Publicado: (2013)

Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese
por: Zhao, Ying, et al.
Publicado: (2014)

SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling
por: XIONG, HUAPING, et al.
Publicado: (2014)

Melatonin is a potential oncostatic agent to inhibit HepG2 cell proliferation through multiple pathways
por: Ammar, Omar A., et al.
Publicado: (2022)

FoxO Proteins in the Nervous System
por: Maiese, Kenneth
Publicado: (2015)

The FoxOs are in the ApoM house
por: Linton, MacRae F., et al.
Publicado: (2022)

Effects of hyperglycemia on the regulation and expression of the Apoe, Igfbp1 and Foxo1 genes and on nuclear phenotypes in HepG2 cells
por: Ghiraldini, Flávia G, et al.
Publicado: (2013)

Synergistic Effect of MC-LR and C-Terminal Truncated HBx on HepG2 Cells and Their Effects on PP2A Mediated Downstream Target of MAPK Signaling Pathway
por: Xiao, Chanchan, et al.
Publicado: (2020)

Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes
por: Zhang, Yi, et al.
Publicado: (2020)

Akt2 mediates glucocorticoid resistance in lymphoid malignancies through FoxO3a/Bim axis and serves as a direct target for resistance reversal
por: Xie, Mixue, et al.
Publicado: (2019)

Overexpression of Chicken IRF7 Increased Viral Replication and Programmed Cell Death to the Avian Influenza Virus Infection Through TGF-Beta/FoxO Signaling Axis in DF-1
por: Kim, Tae Hyun, et al.
Publicado: (2018)

17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation
por: Guo, Yusheng, et al.
Publicado: (2021)

FoxO3 suppresses Myc-driven lymphomagenesis
por: Vandenberg, C J, et al.
Publicado: (2016)

FoxO gene family evolution in vertebrates
por: Wang, Minghui, et al.
Publicado: (2009)

Redox regulation of FoxO transcription factors
por: Klotz, Lars-Oliver, et al.
Publicado: (2015)

FoxO1 breaks diabetic heart
por: Nagao, Mototsugu, et al.
Publicado: (2013)

FoxO transcription factors in mitochondrial homeostasis
por: Cheng, Zhiyong
Publicado: (2022)

The FoxO3 gene and cause‐specific mortality
por: Willcox, Bradley J., et al.
Publicado: (2016)

Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter
por: Tian, Yu-Nan, et al.
Publicado: (2020)

Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells
por: Wells, Kristen L, et al.
Publicado: (2020)

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
por: Gilley, Jonathan, et al.
Publicado: (2003)

Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways
por: Chi, Meng-yi, et al.
Publicado: (2022)

Artificial cells eavesdropping on HepG2 cells
por: Westensee, Isabella Nymann, et al.
Publicado: (2023)

FoxO and Stress Responses in the Cnidarian Hydra vulgaris
por: Bridge, Diane, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_33i1oa9v84vpdaki71imeeq2h6