Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations

BACKGROUND: There are no reliable markers of malignancy in phaeochromocytomas (PCC) and paragangliomas (PGL). We investigated the relevance of the mammalian target of rapamycin (mTOR)/AKT and hypoxic pathways as novel immunohistochemical markers of malignancy. METHODS: Tissue microarray blocks were...

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Detalles Bibliográficos
Autores principales: Pinato, D J, Ramachandran, R, Toussi, S T K, Vergine, M, Ngo, N, Sharma, R, Lloyd, T, Meeran, K, Palazzo, F, Martin, N, Khoo, B, Dina, R, Tan, T M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566818/
https://www.ncbi.nlm.nih.gov/pubmed/23257898
http://dx.doi.org/10.1038/bjc.2012.538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566818/
https://www.ncbi.nlm.nih.gov/pubmed/23257898
http://dx.doi.org/10.1038/bjc.2012.538

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