Lack of correlation between predicted and actual off-target effects of short-interfering RNAs targeting the human papillomavirus type 16 E7 oncogene

BACKGROUND: When designing therapeutic short-interfering RNAs (siRNAs), off-target effects (OTEs) are usually predicted by computational quantification of messenger RNAs (mRNAs) that contain matches to the siRNA seed sequence in their 3′ UTRs. It is assumed that the higher the number of predicted tr...

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Detalles Bibliográficos
Autores principales: Hanning, J E, Saini, H K, Murray, M J, van Dongen, S, Davis, M P A, Barker, E M, Ward, D M, Scarpini, C G, Enright, A J, Pett, M R, Coleman, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Genetics & Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566827/
https://www.ncbi.nlm.nih.gov/pubmed/23299538
http://dx.doi.org/10.1038/bjc.2012.564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566827/
https://www.ncbi.nlm.nih.gov/pubmed/23299538
http://dx.doi.org/10.1038/bjc.2012.564

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