Cargando…
An improved synthesis of a fluorophosphonate–polyethylene glycol–biotin probe and its use against competitive substrates
The fluorophosphonate (FP) moiety attached to a biotin tag is a prototype chemical probe used to quantitatively analyze and enrich active serine hydrolases in complex proteomes in an approach called activity-based protein profiling (ABPP). In this study we have designed a novel synthetic route to a...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566859/ https://www.ncbi.nlm.nih.gov/pubmed/23400700 http://dx.doi.org/10.3762/bjoc.9.12 |