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Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is associated with caspase activation. However, a role for pro-inflammatory caspases or inflammasomes has not been explored in diet-induced liver injury. Our aims were to examine the role of caspase-1 in high fat-induced NASH. C57BL/6 wild-type and caspase 1-knock...

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Detalles Bibliográficos
Autores principales: Dixon, Laura J., Flask, Chris A., Papouchado, Bettina G., Feldstein, Ariel E., Nagy, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567081/
https://www.ncbi.nlm.nih.gov/pubmed/23409132
http://dx.doi.org/10.1371/journal.pone.0056100