Silencing Mutated β-Catenin Inhibits Cell Proliferation and Stimulates Apoptosis in the Adrenocortical Cancer Cell Line H295R

CONTEXT: Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin signaling pathway seem...

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Detalles Bibliográficos
Autores principales: Gaujoux, Sébastien, Hantel, Constanze, Launay, Pierre, Bonnet, Stéphane, Perlemoine, Karine, Lefèvre, Lucile, Guillaud-Bataille, Marine, Beuschlein, Felix, Tissier, Frédérique, Bertherat, Jérôme, Rizk-Rabin, Marthe, Ragazzon, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567123/
https://www.ncbi.nlm.nih.gov/pubmed/23409032
http://dx.doi.org/10.1371/journal.pone.0055743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567123/
https://www.ncbi.nlm.nih.gov/pubmed/23409032
http://dx.doi.org/10.1371/journal.pone.0055743

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