Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling

Deletion of tumor suppressor genes in stromal fibroblasts induces epithelial cancer development, suggesting an important role of stroma in epithelial homoeostasis. However, the underlying mechanisms remain to be elucidated. Here we report that deletion of the gene encoding TGFβ receptor 2 (Tgfbr2) i...

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Detalles Bibliográficos
Autores principales: Achyut, B. R., Bader, David A., Robles, Ana I., Wangsa, Darawalee, Harris, Curtis C., Ried, Thomas, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567148/
https://www.ncbi.nlm.nih.gov/pubmed/23408900
http://dx.doi.org/10.1371/journal.pgen.1003251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567148/
https://www.ncbi.nlm.nih.gov/pubmed/23408900
http://dx.doi.org/10.1371/journal.pgen.1003251

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