Cargando…

Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling

Deletion of tumor suppressor genes in stromal fibroblasts induces epithelial cancer development, suggesting an important role of stroma in epithelial homoeostasis. However, the underlying mechanisms remain to be elucidated. Here we report that deletion of the gene encoding TGFβ receptor 2 (Tgfbr2) i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Achyut, B. R., Bader, David A., Robles, Ana I., Wangsa, Darawalee, Harris, Curtis C., Ried, Thomas, Yang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567148/ https://www.ncbi.nlm.nih.gov/pubmed/23408900 http://dx.doi.org/10.1371/journal.pgen.1003251

Ejemplares similares

Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes
por: Bowen, Steven, et al.
Publicado: (2013)

An Improved Breast Epithelial Sampling Method for Molecular Profiling and Biomarker Analysis in Women at Risk for Breast Cancer
por: Danforth, David N, et al.
Publicado: (2015)

Inferring models of multiscale copy number evolution for single-tumor phylogenetics
por: Chowdhury, Salim Akhter, et al.
Publicado: (2015)

Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression
por: Braun, Rüdiger, et al.
Publicado: (2019)

FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe
por: Gertz, E. Michael, et al.
Publicado: (2016)

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis
por: Trakala, Marianna, et al.
Publicado: (2021)

Effects of human sex chromosome dosage on spatial chromosome organization
por: Jowhar, Ziad, et al.
Publicado: (2018)

A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug
por: Chen, Chen, et al.
Publicado: (2017)

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
por: Sciascia, Nicholas, et al.
Publicado: (2020)

Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-β
por: Enders, G A
Publicado: (2007)

Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis
por: Meyer, C, et al.
Publicado: (2013)

OX40 ligand expression abrogates the immunosuppressive function of retinal pigment epithelium
por: Cunningham, Matthew A, et al.
Publicado: (2013)

Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases
por: Rausch, Valentin, et al.
Publicado: (2017)

Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells
por: Galofré, Claudia, et al.
Publicado: (2020)

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies
por: Patkar, Sushant, et al.
Publicado: (2021)

Maladaptive TGF-β Signals to the Alveolar Epithelium Drive Fibrosis after COVID-19 Infection
por: Yao, Changfu, et al.
Publicado: (2023)

Chromosome mis-segregation and cytokinesis failure in trisomic human cells
por: Nicholson, Joshua M, et al.
Publicado: (2015)

Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium
por: Hirose, Wataru, et al.
Publicado: (2022)

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance
Publicado: (1996)

Abrogation of TGF-beta signalling in TAGLN expressing cells recapitulates Pentalogy of Cantrell in the mouse
por: Aldeiri, Bashar, et al.
Publicado: (2018)

Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments
por: Wei, Darmood, et al.
Publicado: (2020)

Microbiota, Epithelium, Inflammation, and TGF-β Signaling: An Intricate Interaction in Oncogenesis
por: Pang, Xin, et al.
Publicado: (2018)

Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression
por: Dasari, Subramanyam, et al.
Publicado: (2018)

TGF-β1 Drives Inflammatory Th Cell But Not Treg Cell Compartment Upon Allergen Exposure
por: Musiol, Stephanie, et al.
Publicado: (2022)

The genetic and epigenetic landscapes of the epithelium in asthma
por: Moheimani, Fatemeh, et al.
Publicado: (2016)

Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration
por: Akagi, Keiko, et al.
Publicado: (2023)

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
por: de Jong, Petrus R., et al.
Publicado: (2016)

Be Neighborly
Publicado: (1871)

Neighbors help neighbors control urban mosquitoes
por: Johnson, Brian J., et al.
Publicado: (2018)

B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression
por: Hou, David, et al.
Publicado: (2023)

Blockade of Treg derived TGF-β abrogates suppression of effector T cell function within the tumor microenvironment
por: Budhu, Sadna, et al.
Publicado: (2013)

Neighbor-Neighbor Correlations Explain Measurement Bias in Networks
por: Wu, Xin-Zeng, et al.
Publicado: (2017)

Stromal Modulators of TGF-β in Cancer
por: Costanza, Brunella, et al.
Publicado: (2017)

Environmental strigolactone drives early growth responses to neighboring plants and soil volume in pea
por: Wheeldon, Cara D., et al.
Publicado: (2022)

The maya and their neighbors.
Publicado: (1940)

Meet the neighbors
por: Short, Ben
Publicado: (2012)

The patwin and their neighbors /
por: Kroeber, A. L. (Alfred Louis), 1876-1960
Publicado: (1932)

Nurses and Neighbors
por: Beecher, Thos. K.
Publicado: (1877)

Telomeres and Their Neighbors
por: Jenner, Leon P., et al.
Publicado: (2022)

Blockade of surface bound TGF-β abrogates Treg suppression of effector T cell function within the tumor microenvironment
por: Budhu, Sadna, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1khft1svma86o0iv5abk1fscf9