A Systems Biology Approach Reveals that Tissue Tropism to West Nile Virus Is Regulated by Antiviral Genes and Innate Immune Cellular Processes

The actions of the RIG-I like receptor (RLR) and type I interferon (IFN) signaling pathways are essential for a protective innate immune response against the emerging flavivirus West Nile virus (WNV). In mice lacking RLR or IFN signaling pathways, WNV exhibits enhanced tissue tropism, indicating tha...

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Detalles Bibliográficos
Autores principales: Suthar, Mehul S., Brassil, Margaret M., Blahnik, Gabriele, McMillan, Aimee, Ramos, Hilario J., Proll, Sean C., Belisle, Sarah E., Katze, Michael G., Gale, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567171/
https://www.ncbi.nlm.nih.gov/pubmed/23544010
http://dx.doi.org/10.1371/journal.ppat.1003168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567171/
https://www.ncbi.nlm.nih.gov/pubmed/23544010
http://dx.doi.org/10.1371/journal.ppat.1003168

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