BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cells. We found that BMP4 cooperates...

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Detalles Bibliográficos
Autores principales: Bernardo, Andreia S., Faial, Tiago, Gardner, Lucy, Niakan, Kathy K., Ortmann, Daniel, Senner, Claire E., Callery, Elizabeth M., Trotter, Matthew W., Hemberger, Myriam, Smith, James C., Bardwell, Lee, Moffett, Ashley, Pedersen, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567433/
https://www.ncbi.nlm.nih.gov/pubmed/21816365
http://dx.doi.org/10.1016/j.stem.2011.06.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567433/
https://www.ncbi.nlm.nih.gov/pubmed/21816365
http://dx.doi.org/10.1016/j.stem.2011.06.015

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