A Detailed Physiologically Based Model to Simulate the Pharmacokinetics and Hormonal Pharmacodynamics of Enalapril on the Circulating Endocrine Renin-Angiotensin-Aldosterone System

The renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathogenesis of cardiovascular disorders including hypertension and is one of the most important targets for drugs. A whole body physiologically based pharmacokinetic (wb PBPK) model integrating this hormone circulation system a...

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Detalles Bibliográficos
Autores principales: Claassen, Karina, Willmann, Stefan, Eissing, Thomas, Preusser, Tobias, Block, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567458/
https://www.ncbi.nlm.nih.gov/pubmed/23404365
http://dx.doi.org/10.3389/fphys.2013.00004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567458/
https://www.ncbi.nlm.nih.gov/pubmed/23404365
http://dx.doi.org/10.3389/fphys.2013.00004

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