Cancer as a moving target: understanding the composition and rebound growth kinetics of recurrent tumors

We introduce a stochastic branching process model of diversity in recurrent tumors whose growth is driven by drug resistance. Here, an initially declining population can escape certain extinction via the production of mutants whose fitness is drawn at random from a mutational fitness landscape. Usin...

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Detalles Bibliográficos
Autores principales: Foo, Jasmine, Leder, Kevin, Mumenthaler, Shannon M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567471/
https://www.ncbi.nlm.nih.gov/pubmed/23396647
http://dx.doi.org/10.1111/eva.12019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567471/
https://www.ncbi.nlm.nih.gov/pubmed/23396647
http://dx.doi.org/10.1111/eva.12019

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