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Cancer as a moving target: understanding the composition and rebound growth kinetics of recurrent tumors
We introduce a stochastic branching process model of diversity in recurrent tumors whose growth is driven by drug resistance. Here, an initially declining population can escape certain extinction via the production of mutants whose fitness is drawn at random from a mutational fitness landscape. Usin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567471/ https://www.ncbi.nlm.nih.gov/pubmed/23396647 http://dx.doi.org/10.1111/eva.12019 |