Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets

Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser(21) in GSK3α and Ser(9) in GSK3β) in response to varied external stimuli. Recent work suggests that GSK3 functions as a negative regulator of platelet...

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Detalles Bibliográficos
Autores principales: Moore, Samantha F., van den Bosch, Marion T. J., Hunter, Roger W., Sakamoto, Kei, Poole, Alastair W., Hers, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567645/
https://www.ncbi.nlm.nih.gov/pubmed/23239877
http://dx.doi.org/10.1074/jbc.M112.429936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567645/
https://www.ncbi.nlm.nih.gov/pubmed/23239877
http://dx.doi.org/10.1074/jbc.M112.429936

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