Impact of human autoantibodies on β(1)-adrenergic receptor conformation, activity, and internalization

AIMS: Autoantibodies against second extracellular loops of β(1)-adrenergic receptors frequent in dilated cardiomyopathy confer myocardial dysfunction presumably via cAMP stimulation. Here, we investigate the autoantibody impact on receptor conformation and function. METHODS AND RESULTS: IgG was prep...

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Detalles Bibliográficos
Autores principales: Bornholz, Beatrice, Weidtkamp-Peters, Stefanie, Schmitmeier, Stephanie, Seidel, Claus A. M., Herda, Lars R., Felix, Stephan B., Lemoine, Horst, Hescheler, Jürgen, Nguemo, Filomain, Schäfer, Christoph, Christensen, Morten O., Mielke, Christian, Boege, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567785/
https://www.ncbi.nlm.nih.gov/pubmed/23208588
http://dx.doi.org/10.1093/cvr/cvs350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567785/
https://www.ncbi.nlm.nih.gov/pubmed/23208588
http://dx.doi.org/10.1093/cvr/cvs350

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