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Effect of cryoprotectants on the porosity and stability of insulin-loaded PLGA nanoparticles after freeze-drying

PLGA nanoparticles are useful to protect and deliver proteins in a localized or targeted manner, with a long-term systemic delivery pattern intended to last for a period of time, depending on polymer bioerosion and biodegradability. However, the principal concern regarding these carriers is the hydr...

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Detalles Bibliográficos
Autores principales: Fonte, Pedro, Soares, Sandra, Costa, Ana, Andrade, José Carlos, Seabra, Vítor, Reis, Salette, Sarmento, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568117/
https://www.ncbi.nlm.nih.gov/pubmed/23507897
http://dx.doi.org/10.4161/biom.23246