Sensitive Detection of Pre-Existing BCR-ABL Kinase Domain Mutations in CD34+ Cells of Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Patients Is Associated with Imatinib Resistance: Implications in the Post-Imatinib Era

BACKGROUND: BCR-ABL kinase domain mutations are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CML) patients. Recent studies indicate the presence of pre-existing BCR-ABL mutations in a higher percentage of CML patients when CD34+ stem/progenitor cells are investiga...

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Detalles Bibliográficos
Autores principales: Iqbal, Zafar, Aleem, Aamer, Iqbal, Mudassar, Naqvi, Mubashar Iqbal, Gill, Ammara, Taj, Abid Sohail, Qayyum, Abdul, ur-Rehman, Najeeb, Khalid, Ahmad Mukhtar, Shah, Ijaz Hussain, Khalid, Muhammad, Haq, Riazul, Khan, Mahwish, Baig, Shahid Mahmood, Jamil, Abid, Abbas, Muhammad Naeem, Absar, Muhammad, Mahmood, Amer, Rasool, Mahmood, Akhtar, Tanveer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568121/
https://www.ncbi.nlm.nih.gov/pubmed/23409026
http://dx.doi.org/10.1371/journal.pone.0055717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568121/
https://www.ncbi.nlm.nih.gov/pubmed/23409026
http://dx.doi.org/10.1371/journal.pone.0055717

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